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A clinical trial on young and middle-aged runners published widely in the Journal of the International Society of Sports Nutrition showed that Nicotinamide Mononucleotide (NMN) supplementation directly to the process of generating energy through the oxidation of compounds in the body (also known as aerobic capacity).
Aging is the main factor that weakens biological processes from the molecular level and directly affects respiratory health, cardiovascular health and muscle function. In fact, as we age, we are more likely to lose skeletal muscle mass due to aging, leading to decreased endurance during exercise and increased susceptibility to injury. Simply put, the ability of older people to recover from injury is quite low.
Previously, several studies in rodents have shown that the combination of exercise and NMN precursor supplementation has synergistic effects. However, it has not yet been proven by clinical experiments. In 2021, a study conducted by the Key Laboratory of Fitness and Health Promotion of Guangzhou Sports University provided a new perspective on the effects of combining exercise and NMN supplementation Has the ability to increase aerobic capacity - increasing endurance for runners.
In fact, when absorbed by the body, NMN will be converted into NAD+ through many biochemical reactions. Exercise at an appropriate frequency increases the rate-limiting enzyme (NAMPT) in metabolism and allows more NMN to be converted to NAD+. On the other hand, this study also shows that the combination of exercise and NMN supplementation helps improve cardiovascular and respiratory health in humans.
The 6-week experiment included the participation of 48 young and middle-aged amateur runners. Participants were randomly divided into 4 groups, each group consisting of 10 men and 2 women with differences in NMN dosage:
Dosage is divided into 2 times/day, once in the morning and once in the afternoon/afternoon before running. In particular, they must ensure complete abstinence from caffeine throughout the process. Combined with NMN supplementation, participants will conduct physical training as usual with each training session lasting 40 - 60 minutes and having 5 - 6 practice runs per week. In addition to assessing endurance, cardiopulmonary function indices were also recorded at baseline and after about 6 weeks of the experiment to generalize the athlete's aerobic capacity.
Typically, aerobic condition is understood as using oxygen for metabolism to create energy when running. Simply put, during aerobic respiration, when inhaling, the body effectively uses all the oxygen it needs to provide energy to cells. When running in an aerobic state, athletes will run easily because the muscles and heart are pumped with enough oxygen to create energy to maintain activity. From there, they can run faster and more durable without losing too much effort.
The results are positive! 48 athletes participating in the experiment noted an improvement in physical fitness and this change depended on the amount of NMN supplemented. Athletes supplementing NMN with a dose of 1200 mg/day achieved higher VO2 max (this is considered the maximum rate of oxygen consumption measured during exercise) and more stable heart rates than those using low doses. or placebo. However, the study also noted that the optimal dose of NMN for each person depends on their constitution, medical condition and frequency of exercise.
Scientists have concluded that supplementing NMN during exercise improves people's ability to use oxygen. Thereby improving cardiovascular health and increasing body endurance. On the other hand, some previous scientific hypotheses also stated that NMN can impact the body through improving muscle mass and absolutely no side effects were recorded during the experiment. in rodents and humans.
Supplementing NMN during exercise helps improve people's ability to use oxygen
Nicotinamide Mononucleotide (NMN) is known as an active ingredient that increases ATP energy production, repairs damaged DNA and activates the longevity gene Sirtuins. Many people have used NMN to start their healthy aging journey, especially in improving their physical endurance compared to just regular exercise.
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